Antibiotic-loving bacteria don't just resist drugs, they get a kick out of them
Developing antibiotic resistance has been found to give the disease-causing bacterium E. coli an additional boost, making it grow faster and become fitter after repeated exposure the antibiotic doxycycline.
The mutations that give E. Coli resistance to doxycycline also made them reproduce faster and grow colonies three times larger than ordinary, non-resistant E. Coli. The research is published in the journal Nature Ecology and Evolution.
The researchers exposed E. Coli to eight rounds of antibiotics over four days. In that period, the bacteria gained a number of mutations. One of the mutations was linked to antibiotic resistance, giving the bacteria more pumps to remove the drug from the cell.
The second mutation was to delete a large section of its genome that is normally involved in helping the bacteria coat a surface by forming a 'biofilm'. This section of DNA is actually the remnants of a virus, which causes the cell to split and spill its contents, helping other cells to grow nearby to form a film.
The E. Coli in the study were grown in a liquid culture, in a similar environment to the human bloodstream. Here, without the need to form a biofilm, the E. Coli cut out this section of DNA – which makes up 4% of its genome – when exposed to doxycycline, allowing it to devote its energy to growing faster and forming larger colonies instead. Even when the exposure to doxycycline was stopped, the bacteria did not lose this newly-gained trait.
"We didn't anticipate the viral change at all," study author Robert Beardmore of the University of Exeter told IBTimes UK. "That was much stronger than the pump mutation in evolutionary terms. We saw more strength with selection and a faster change on quite a large chunk of the genome."
This property was not unique to doxycycline, and similar features were found in two different classes of antibiotics, Beardmore said. However, only certain strains of E. Coli gained these mutations when exposed to the antibiotic.
"It's not every antibiotic and it's not every E. Coli, and certainly not every bacterium. But it is pretty strange that that feature is there," Beardmore said. "There's something special about the way doxycycline is inhibiting the cell that causes these features."
Doxycycline is a broad-spectrum antibiotic used for a number of infections, such as chlamydia, Lyme disease, pneumonia and acne. It's also used as a preventative treatment for malaria, and can be taken for months for a trip to a country where the disease is prevalent. This widespread use means the antibiotic can be found in the environment, such as in rivers and soil.
If E. Coli is exposed to doxycycline in the environment, it could quickly develop the mutations to grow larger colonies as well as becoming resistant to the antibiotic, Beardmore said. However, he said that doxycycline should not be dropped as a treatment for various kinds of infection.
"Doxycycline may be a perfectly good drug to treat a range of bacteria with. But when E. Coli comes into contact with it in a river or field, if it's got the right kind of genome then you'll see these effects and doxycycline will boost the growth."
Source: http://www.ibtimes.co.uk/antibiotic-loving-bacteria-dont-just-resist-drugs-they-get-kick-out-them-1603881
what is the cost of viagra tablets in india
generic cialis
power v8 viagra forum
viagra usa
where to get the cheapest cialis
buy generic viagra
how do you know if someone has taken viagra
cheap generic viagra
quando prendere cialis 5 mg
cheap viagra
how long i can use viagra
viagra for men.viagra without prescription
andropausa viagra
viagra pills for sale
cialis and retinal detachment
generic cialis online
viagra preis apotheke deutschland
cheap viagra
red eyes after cialis
generic cialis online
Sunday, June 7, 2026
Dapoxetine - Sexual Health - Patient guide
dapoxetine can be useful medicine, but best results usually come from ordinary routines repeated with care. Doctors use it for patients looking for treatment for premature ejaculation. Strong outcomes usually come from steady use, not guesswork. Patients who track symptoms, timing, and changes around treatment often give clinicians better information for later decisions. For medicine specific background, patients can review https://lucasclinic.com/sexual-health/dapoxetine/. Resource is useful because it explains why treatment should be individualized rather than copied from another person's routine. Daily consistency usually matters. Taking medicine at planned time, keeping updated medication list, and reporting new prescriptions or supplements can prevent small problems from becoming larger ones. Missed doses, sudden schedule changes, or self directed adjustments often create confusion that later looks like treatment failure. Patients should also remember that treatment sits inside sexual health support, not in isolation. Sleep, diet, hydration, activity, and underlying conditions can shape how well plan works. That is why follow up visits should review whole pattern rather than one symptom in a vacuum. Follow through after prescription also matters. Refills should be planned before bottles run low, symptom notes should be brought to visits, and any major change in routine should be mentioned early. Many medication problems are easier to fix when clinician hears about them after first week of trouble rather than after several months of guessing. Patients should know which symptoms are worth quick call. Concerning problems can include dizziness, fainting, severe headache, or ongoing sexual side effects. Even when symptom has other possible causes, early reporting gives clinician better chance to sort out whether medicine, dose, or unrelated illness needs attention. A broader overview of related treatment appears at https://lucasclinic.com/sexual-health/. That perspective can help patients understand why lifestyle support, monitoring, and symptom review remain important alongside prescription itself. Clear expectations, steady routine, and early symptom reporting usually make this treatment safer and easier to manage over time.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.